MCPIP1 promotes cell proliferation, migration and angiogenesis of glioma via VEGFA-mediated ERK pathway

Exp Cell Res. 2022 Sep 1;418(1):113267. doi: 10.1016/j.yexcr.2022.113267. Epub 2022 Jun 22.

Abstract

Glioma is the most common primary malignant intracranial tumor in the population, and is often associated with abundant angiogenesis. However, how angiogenesis is regulated during glioma progression is still poorly understood. Data mining of cancer patient database shows that MCPIP1 is positively correlated with VEGFA expression and negatively with survival. In this study, we report that overexpressed MCPIP1 in glioma cells is a boost of angiogenesis. Mechanistically, MCPIP1 upregulates the expression of VEGFA in glioma, and promote the secretion of VEGFA to the surroundings, which could stimulate angiogenesis through ERK pathway. Blocking VEGFA expression and secretion inhibited MCPIP1-mediated angiogenesis and glioma progression in vitro and xenograft models. Collectively, these results identify a critical role for MCPIP1 in angiogenesis and glioma progression by regulating the VEGFA-mediated ERK pathway, suggesting that targeting MCPIP1 may be a potential glioma-selective therapeutic strategy.

Keywords: Angiogenesis; ERK pathway; Glioma; MCPIP1; VEGFA.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation / genetics
  • Gene Expression Regulation, Neoplastic
  • Glioma* / pathology
  • Humans
  • MAP Kinase Signaling System* / genetics
  • MAP Kinase Signaling System* / physiology
  • Neovascularization, Pathologic / metabolism
  • Ribonucleases* / genetics
  • Ribonucleases* / metabolism
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism
  • Vascular Endothelial Growth Factor A / genetics
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Transcription Factors
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Ribonucleases
  • ZC3H12A protein, human