Light-responsive biomaterials for ocular drug delivery

Hend A M Abdelmohsen; Nikki A Copeland; John G Hardy

doi:10.1007/s13346-022-01196-5

Light-responsive biomaterials for ocular drug delivery

Drug Deliv Transl Res. 2023 Aug;13(8):2159-2182. doi: 10.1007/s13346-022-01196-5. Epub 2022 Jun 24.

Authors

Hend A M Abdelmohsen^{1

2

3}, Nikki A Copeland^{2

4}, John G Hardy^{5

6}

Affiliations

¹ Department of Chemistry, Lancaster University, Lancaster, LA1 4YB, Lancashire, UK.
² Division of Biomedical and Life Sciences, Lancaster University, Lancaster, LA1 4YW, Lancashire, UK.
³ Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, African Union Organization Street, Abbassia, Cairo, 11566, Egypt.
⁴ Materials Science Institute, Lancaster University, Lancaster, LA1 4YB, Lancashire, UK.
⁵ Department of Chemistry, Lancaster University, Lancaster, LA1 4YB, Lancashire, UK. j.g.hardy@lancaster.ac.uk.
⁶ Materials Science Institute, Lancaster University, Lancaster, LA1 4YB, Lancashire, UK. j.g.hardy@lancaster.ac.uk.

Abstract

Light-responsive biomaterials can be used for the delivery of therapeutic drugs and nucleic acids, where the tunable/precise delivery of payload highlights the potential of such biomaterials for treating a variety of conditions. The translucency of eyes and advances of laser technology in ophthalmology make light-responsive delivery of drugs feasible. Importantly, light can be applied in a non-invasive fashion; therefore, light-triggered drug delivery systems have great potential for clinical impact. This review will examine various types of light-responsive polymers and the chemistry that underpins their application as ophthalmic drug delivery systems.

Keywords: Light-responsive; Light-triggered; Ocular drug delivery; Photobiology; Photochemistry; Stimuli-responsive.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials*
Drug Delivery Systems*
Polymers

Substances

Biocompatible Materials
Polymers