Baseline Hemodynamic Impairment and Revascularization Outcome in Newly Diagnosed Adult Moyamoya Disease Determined by Pseudocontinuous Arterial Spin Labeling

Abstract

Objective: The study aimed to investigate the hemodynamic features and independent predictors of neoangiogenesis after revascularization in moyamoya disease (MMD) by pseudocontinuous arterial spin labeling magnetic resonance imaging (pCASL MRI).

Methods: Thirty-nine MMD patients were categorized into infarction group, hemorrhagic group, and atypical group. All patients underwent combined bypass surgery and pCASL MRI with postlabeling delays (PLD) of 1525 ms and 2525 ms. Absolute CBF_MCA (cerebral blood flow in middle cerebral artery territory), relative CBF_MCA (CBF_MCA 2525 ms/CBF_MCA 1525 ms), and spatial coefficient of variation of MCA (CoV_MCA) were analyzed. Relationships between CBF_MCA and the following clinical parameters were assessed: Suzuki stage, modified Rankin scale (mRS), cerebrovascular accident lesion score, and deep medullary veins score. Potential predictors for favorable neoangiogenesis and hemodynamic changes were explored as well.

Results: Preoperative CBF_MCA differed among MMD patients with variable clinical presentations, Matsushima stages, modified Rankin Scale scores, CVA scores, and deep medullary vein scores. After bypass surgery, mean CBF_MCA increased significantly in the infarction group (P = 0.027) and decreased in the hemorrhagic group (P = 0.043), while spatial CoV_MCA was observed to decline in all groups. Higher preoperative relative CBF_MCA and spatial CoV_MCA were independent predictors for robust neoangiogenesis after bypass. The cutoff value of 0.330 of spatial CoV_MCA at long PLD yielded the best sensitivity at 82.1% and specificity at 81.8%. Furthermore, both preoperative relative CBF_MCA and spatial CoV_MCA showed mild positive correlations with ΔmRS in MMD patients.

Conclusions: pCASL-MRI with multiple PLDs could reflect preoperative hemodynamic impairment and predict the neoangiogenesis after combined bypass surgery in moyamoya patients.

Keywords: Cerebral blood flow; Moyamoya; Pseudocontinuous arterial spin labeling; Spatial coefficient of variation; Susceptibility weighted imaging.