Supramolecular glycopolymers: How carbohydrates matter in structure, dynamics, and function

Lu Su; Simone I S Hendrikse; E W Meijer

doi:10.1016/j.cbpa.2022.102171

Supramolecular glycopolymers: How carbohydrates matter in structure, dynamics, and function

Curr Opin Chem Biol. 2022 Aug:69:102171. doi: 10.1016/j.cbpa.2022.102171. Epub 2022 Jun 21.

Authors

Lu Su¹, Simone I S Hendrikse², E W Meijer³

Affiliations

¹ Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven 5600 MB, the Netherlands; Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden 2333 CC, the Netherlands.
² Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven 5600 MB, the Netherlands; Department of Chemical Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia.
³ Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, Eindhoven 5600 MB, the Netherlands; School of Chemistry and UNSW RNA Institute, The University of New South Wales Sydney, NSW 2052, Australia. Electronic address: e.w.meijer@tue.nl.

PMID: 35749930
DOI: 10.1016/j.cbpa.2022.102171

Abstract

Supramolecular glycopolymers exhibiting inherent dynamicity, tunability, and adaptivity allow us to arrive at a deeper understanding of multivalent carbohydrate-carbohydrate interactions and carbohydrate-protein interactions, both being essential to key biological events. The impacts of the carbohydrate segments in these supramolecular glycopolymers towards their structure, dynamics, and function as biomaterials are addressed in this minireview. Bottlenecks and challenges are discussed, and we speculate about possible future directions.

Keywords: Biomaterials; Dynamics; Non-covalent interactions; Supramolecular glycopolymers.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrates* / chemistry

Substances

Carbohydrates