Asprosin and meteorin-like protein immunoreactivity in invasive ductal breast carcinoma stages

Gulsum Akkus; Leyla Canpolat Koyuturk; Mustafa Yilmaz; Serhat Hancer; Ibrahim Hanifi Ozercan; Tuncay Kuloglu

doi:10.1016/j.tice.2022.101855

Asprosin and meteorin-like protein immunoreactivity in invasive ductal breast carcinoma stages

Tissue Cell. 2022 Aug:77:101855. doi: 10.1016/j.tice.2022.101855. Epub 2022 Jun 17.

Authors

Gulsum Akkus¹, Leyla Canpolat Koyuturk², Mustafa Yilmaz³, Serhat Hancer⁴, Ibrahim Hanifi Ozercan⁵, Tuncay Kuloglu⁶

Affiliations

¹ Firat University, Medical School, Department of Histology and Embriyology, Elazig, Turkey. Electronic address: akgulsum76@gmail.com.
² Firat University, Medical School, Department of Histology and Embriyology, Elazig, Turkey. Electronic address: lcan@firat.edu.tr.
³ Firat University, Medical School, Department of Emergency Medicine, Elazig, Turkey. Electronic address: drmylmz@hotmail.com.
⁴ Firat University, Medical School, Department of Histology and Embriyology, Elazig, Turkey. Electronic address: serhathancer87@gmail.com.
⁵ Firat University, Medical School, Department of Pathology, Elazig, Turkey. Electronic address: ozercanih@hotmail.com.
⁶ Firat University, Medical School, Department of Histology and Embriyology, Elazig, Turkey. Electronic address: tkuloglu@firat.edu.tr.

PMID: 35749857
DOI: 10.1016/j.tice.2022.101855

Abstract

Aim: The study aimed to investigate asprosin (ASP) and meteorin-like (METRNL) protein immunoreactivity in invasive ductal breast cancer.

Materials and methods: Overall, 60 cases of invasive ductal breast cancer (20 cases each of Grade 1, 2 and 3) were evaluated in addition to 20 normal breast tissues obtained from the Pathology Department Archive. ASP and METRNL expressions were assessed using immunohistochemical staining and visualised under a light microscope.

Results: There was a significant difference in ASP and METRNL immunoreactivity among all the groups included in the study (p < 0.001). Cancer tissues with Grade 1, 2 and 3 showed a significant increase in ASP and METRNL immunoreactivity compared with the control group; however, no significant difference was noted among the cancer tissues with Grade 1, 2 and 3.

Conclusions: ASP and METRNL immunoreactivity increased at the cellular level in invasive ductal breast cancer, but there was no difference in immunoreactivity among the breast cancer grades.

Keywords: Asprosin; Histopathology; Invasive ductal breast cancer; Meteorin-like protein.

MeSH terms

Breast Neoplasms*
Female
Humans