Antidepressant alkaloids from the rhizomes of Corydalis decumbens

Qin-Ge Ma; Ye Tang; Mao-Hua He; Rong-Rui Wei

doi:10.1515/znc-2021-0108

Antidepressant alkaloids from the rhizomes of Corydalis decumbens

Z Naturforsch C J Biosci. 2022 Jun 24;77(11-12):501-507. doi: 10.1515/znc-2021-0108. Print 2022 Nov 25.

Authors

Qin-Ge Ma¹, Ye Tang¹, Mao-Hua He¹, Rong-Rui Wei¹

Affiliation

¹ Key Laboratory of Modern Preparation of Chinese Medicine of Ministry of Education & Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, P. R. China.

PMID: 35749126
DOI: 10.1515/znc-2021-0108

Abstract

Two new alkaloids (1 and 2), named 1,7-dimethoxy-2'-prenyl-1',9-dihydropyrrolo-carbazole (1) and 1,7-dimethoxy-4',5'-dimethylcyclopenta-carbazole-1',3'-dione (2), along with thirteen known alkaloids (3-15) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl₃ extraction of Corydalis decumbens for the first time. Their structures were determined by NMR, MS, IR, UV, and related references. Compounds (1-15) were evaluated for their antidepressant activities by measuring inhibition of monoamine neurotransmitter reuptake in vitro. Among them, compounds 1, 2, 4, and 6 showed certain antidepressant activities.

Keywords: Corydalis decumbens; alkaloid; antidepressant.

MeSH terms

Alkaloids* / chemistry
Antidepressive Agents
Carbazoles
Corydalis* / chemistry
Rhizome

Substances

Alkaloids
Antidepressive Agents
Carbazoles