The Role of Podoplanin in the Immune System and Inflammation

Zhiyuan Zhang; Nan Zhang; Jing Yu; Wenting Xu; Jiameng Gao; Xin Lv; Zongmei Wen

doi:10.2147/JIR.S366620

The Role of Podoplanin in the Immune System and Inflammation

J Inflamm Res. 2022 Jun 17:15:3561-3572. doi: 10.2147/JIR.S366620. eCollection 2022.

Authors

Zhiyuan Zhang^#¹, Nan Zhang^#¹, Jing Yu^#¹, Wenting Xu¹, Jiameng Gao¹, Xin Lv¹, Zongmei Wen¹

Affiliation

¹ Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, People's Republic of China.

^# Contributed equally.

Abstract

Podoplanin is a small cell-surface mucin-like glycoprotein that participates in multiple physiological and pathological processes. Podoplanin exerts an important function in the immune response and is upregulated in fibroblasts, macrophages, T helper cells, and epithelial cells during inflammation. Herein, we summarize the latest knowledge on the functional expression of podoplanin in the immune system and review the contribution of podoplanin to several inflammatory diseases. Furthermore, we discuss podoplanin as a novel therapeutic target for various inflammatory diseases.

Keywords: immune system; inflammation; podoplanin.

Publication types

Review

Grants and funding

This work was supported by the National Natural Science Foundation of China [grant numbers: 81871601 and 82170107] and the Foundation of the Science and Technology Commission of Shanghai Municipality (19ZR1443000).