Analysis of the Effect of Tumor-Grade Change on the Prognosis of Retroperitoneal Sarcoma

Sung Jun Jo; Kyeong Deok Kim; So Hee Lim; Jinseob Kim; Min Jung Kim; Jae Berm Park; Kyo Won Lee

doi:10.3390/cancers14123020

Analysis of the Effect of Tumor-Grade Change on the Prognosis of Retroperitoneal Sarcoma

Cancers (Basel). 2022 Jun 19;14(12):3020. doi: 10.3390/cancers14123020.

Authors

Sung Jun Jo¹, Kyeong Deok Kim², So Hee Lim¹, Jinseob Kim³, Min Jung Kim⁴, Jae Berm Park¹, Kyo Won Lee¹

Affiliations

¹ Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
² Department of Surgery, Inha University Hospital, Inha University School of Medicine, Incheon 22332, Korea.
³ Department of Epidemiology, School of Public Health, Seoul National University, Seoul 08826, Korea.
⁴ Department of Surgery, Seoul Medical Center, Seoul 02053, Korea.

Abstract

In retroperitoneal sarcoma (RPS), the change in the tumor grade from the primary tumor to the first local recurrence, and the effect of this change on prognosis, are unknown. The aim of this study is to analyze whether these changes affect the prognosis of RPS. Patients who underwent surgery for a first locally recurrent RPS at Samsung Medical Center from January 2001 to February 2020 were included. The pathologic features of primary and recurrent tumors were compared, and the outcomes were measured. A total of 49 patients were investigated. There were 25 patients with different grades of primary and recurrent tumors. The improving, stable, and worsening groups contained 16 (32.7%), 24 (49%), and 9 (18.3%) patients, respectively. There was no significant difference in the prognosis between the three groups. In the analyses of the factors that affect the OS, a high grade of the primary tumor (p = 0.023) and the size of the recurrent tumor (p = 0.032) were statistically significant in both univariate and multivariate analyses. In a factor analysis of the second LR, a high-grade recurrent tumor (p = 0.032) was the only significant factor. There were tumor-grade changes between the primary tumor and recurrent tumor in RPS. However, the most important factor in prognosis is a high grade of the primary tumor.

Keywords: RPS; grade change; second LR.

Grants and funding

This research was supported by SungKyunKwan University and the BK21 FOUR (Graduate School of Innovation), and funded by the Ministry of Education (MOE, Korea) and the National Research Foundation of Korea (NRF).