An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin

Sepideh Bastani; Vahid Vahedian; Mohsen Rashidi; Amirabbas Mir; Sepideh Mirzaei; Iraj Alipourfard; Farhad Pouremamali; Hamidreza Nejabati; Jamileh Kadkhoda; Nazila Fathi Maroufi; Maryam Akbarzadeh

doi:10.1016/j.biopha.2022.113297

An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin

Biomed Pharmacother. 2022 Sep:153:113297. doi: 10.1016/j.biopha.2022.113297. Epub 2022 Jun 20.

Authors

Affiliations

¹ Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
² Cancer Biology Research Group, Faculty of Medicine Institute of Biotechnology (FMB-IBTEC) Sao Paulo State University (UNESP), Brazil.
³ Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
⁴ Institute of Nano Science and Nano Technology, University of Kashan, P.O. Box 87317-51167, Kashan, Islamic Republic of Iran.
⁵ Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran.
⁶ Institutitue of Biology, Biotechnology and Environmental Protection - Faculty of Natural Sciences - University of Silesia - Katowice - Poland.
⁷ Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
⁸ Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁹ Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
¹⁰ Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: n.fathi6788@gmail.com.
¹¹ Department of Biochemistry, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address: m.akbarzadeh@erasmusmc.nl.

PMID: 35738178
DOI: 10.1016/j.biopha.2022.113297

Abstract

Crocin, an active ingredient derived from saffron, is one of the herbal components that has recently been considered by researchers. Crocin has been shown to have many anti-inflammatory and antioxidant properties, and therefore can be used to treat various diseases. It has been shown that Crocin has a positive effect on the prevention and treatment of cardiovascular disease, cancer, diabetes, and kidney disease. In addition, the role of this substance in COVID-19 pandemic has been identified. In this review article, we tried to have a comprehensive review of the antioxidant and anti-inflammatory effects of Crocin in different diseases and different tissues. In conclusion, Crocin may be helpful in pathological conditions that are associated with inflammation and oxidative stress.

Keywords: Anti-inflammatory; Anti-oxidant; Cancer; Covid19; Crocin.

Publication types

Review

MeSH terms

Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use
Antioxidants* / pharmacology
Antioxidants* / therapeutic use
COVID-19 Drug Treatment*
Carotenoids
Humans
Pandemics

Substances

Anti-Inflammatory Agents
Antioxidants
Carotenoids
crocin