Changing the course of Earth's climate is increasingly urgent, but there is also a concurrent need for proactive stewardship of the adaptive capacity of the rapidly changing biosphere. Adaptation ultimately underpins the resilience of Earth's complex systems; species, communities, and ecosystems shift and evolve over time. Yet oncoming changes will seriously challenge current natural resource management and conservation efforts. We review forward-looking conservation approaches to enable adaptation and resilience. Key opportunities include expanding beyond preservationist approaches by including those that enable and facilitate ecological change. Conservation should not just focus on climate change losers but also on proactive management of emerging opportunities. Local efforts to conserve biodiversity and generate habitat complexity will also help to maintain a diversity of future options for an unpredictable future.