Pro-Gastrin-Releasing Peptide as a Marker of Small Cell Lung Cancer

N V Lyubimova; A E Kuz'minov; A A Markovich; A V Lebedeva; Yu S Timofeev; I S Stilidi; N E Kushlinskii

doi:10.1007/s10517-022-05529-9

Pro-Gastrin-Releasing Peptide as a Marker of Small Cell Lung Cancer

Bull Exp Biol Med. 2022 Jun;173(2):257-260. doi: 10.1007/s10517-022-05529-9. Epub 2022 Jun 23.

Authors

N V Lyubimova¹, A E Kuz'minov¹, A A Markovich¹, A V Lebedeva¹, Yu S Timofeev¹, I S Stilidi¹, N E Kushlinskii²

Affiliations

¹ N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
² N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia. kne3108@gmail.com.

PMID: 35737164
DOI: 10.1007/s10517-022-05529-9

Abstract

The serum levels of pro-gastrin-releasing peptide (proGRP), neuron-specific enolase (NSE), and chromogranin A (CgA) were studied in 69 patients with small cell lung cancer and 50 apparently healthy donors. A significant increase of all studied biochemical markers was revealed in small cell lung cancer patients, while the highest diagnostic efficiency was demonstrated by proGRP compared to NSE and CgA. ProGRP is a promising biochemical marker of small cell lung cancer, especially sensitive in patients with distant metastases (in the brain, liver, and bones).

Keywords: blood serum; chromogranin A; neuron-specific enolase; pro-gastrin-releasing peptide; small cell lung cancer.

MeSH terms

Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Chromogranin A
Gastrin-Releasing Peptide
Humans
Lung Neoplasms* / diagnosis
Lung Neoplasms* / metabolism
Lung Neoplasms* / pathology
Phosphopyruvate Hydratase / blood
Small Cell Lung Carcinoma* / diagnosis
Small Cell Lung Carcinoma* / metabolism
Small Cell Lung Carcinoma* / pathology

Substances

Biomarkers, Tumor
Chromogranin A
Gastrin-Releasing Peptide
Phosphopyruvate Hydratase