Image Quality and Radiation Dose of Contrast-Enhanced Chest-CT Acquired on a Clinical Photon-Counting Detector CT vs. Second-Generation Dual-Source CT in an Oncologic Cohort: Preliminary Results

Florian Hagen; Lukas Walder; Jan Fritz; Ralf Gutjahr; Bernhard Schmidt; Sebastian Faby; Fabian Bamberg; Stefan Schoenberg; Konstantin Nikolaou; Marius Horger

doi:10.3390/tomography8030119

Image Quality and Radiation Dose of Contrast-Enhanced Chest-CT Acquired on a Clinical Photon-Counting Detector CT vs. Second-Generation Dual-Source CT in an Oncologic Cohort: Preliminary Results

Tomography. 2022 Jun 3;8(3):1466-1476. doi: 10.3390/tomography8030119.

Authors

Affiliations

¹ Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72070 Tübingen, Germany.
² NYU Grossman School of Medicine, Department of Radiology, New York, NY 10016, USA.
³ Siemens Healthcare GmbH, 91052 Erlangen, Germany.
⁴ Department of Radiology, Albert-Ludwigs-University Freiburg, 79106 Freiburg, Germany.
⁵ Department of Radiology, University of Mannheim, 68167 Mannheim, Germany.

Abstract

Our aim was to compare the image quality and patient dose of contrast-enhanced oncologic chest-CT of a first-generation photon-counting detector (PCD-CT) and a second-generation dual-source dual-energy CT (DSCT). For this reason, one hundred consecutive oncologic patients (63 male, 65 ± 11 years, BMI: 16−42 kg/m2) were prospectively enrolled and evaluated. Clinically indicated contrast-enhanced chest-CT were obtained with PCD-CT and compared to previously obtained chest-DSCT in the same individuals. The median time interval between the scans was three months. The same contrast media protocol was used for both scans. PCD-CT was performed in QuantumPlus mode (obtaining full spectral information) at 120 kVp. DSCT was performed using 100 kV for Tube A and 140 kV for Tube B. “T3D” PCD-CT images were evaluated, which emulate conventional 120 keV polychromatic images. For DSCT, the convolution algorithm was set at I31f with class 1 iterative reconstruction, whereas comparable Br40 kernel and iterative reconstruction strengths (Q1 and Q3) were applied for PCD-CT. Two radiologists assessed image quality using a five-point Likert scale and performed measurements of vessels and lung parenchyma for signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and in the case of pulmonary metastases tumor-to-lung parenchyma contrast ratio. PCD-CT CNRvessel was significantly higher than DSCT CNRvessel (all, p < 0.05). Readers rated image contrast of mediastinum, vessels, and lung parenchyma significantly higher in PCD-CT than DSCT images (p < 0.001). Q3 PCD-CT CNRlung_parenchyma was significantly higher than DSCT CNRlung_parenchyma and Q1 PCD-CT CNRlung_parenchyma (p < 0.01). The tumor-to-lung parenchyma contrast ratio was significantly higher on PCD-CT than DSCT images (0.08 ± 0.04 vs. 0.03 ± 0.02, p < 0.001). CTDI, DLP, SSDE mean values for PCD-CT and DSCT were 4.17 ± 1.29 mGy vs. 7.21 ± 0.49 mGy, 151.01 ± 48.56 mGy * cm vs. 288.64 ± 31.17 mGy * cm and 4.23 ± 0.97 vs. 7.48 ± 1.09, respectively. PCD-CT enables oncologic chest-CT with a significantly reduced dose while maintaining image quality similar to a second-generation DSCT for comparable protocol settings.

Keywords: chest-CT; dual-source dual-energy CT; image quality; photon-counting CT; radiation dose.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Humans
Male
Radiation Dosage
Signal-To-Noise Ratio
Thorax*
Tomography, X-Ray Computed* / methods

Grants and funding

This project is funded by the Baden-Württemberg Ministry of Economic Affairs, Labor and Tourism as part of the “Forum Gesundheitsstandort Baden-Württemberg, number: 35-4223.10/20.