Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ dtlA Mutant of a Marine-Derived Streptomyces Strain

Jing Liu; Huayue Li; Zengzhi Liu; Tong Li; Fei Xiao; Wenli Li

doi:10.3390/md20060394

Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ dtlA Mutant of a Marine-Derived Streptomyces Strain

Mar Drugs. 2022 Jun 15;20(6):394. doi: 10.3390/md20060394.

Authors

Jing Liu¹, Huayue Li^{1

2}, Zengzhi Liu¹, Tong Li¹, Fei Xiao¹, Wenli Li^{1

2}

Affiliations

¹ Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
² Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.

Abstract

Two new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 (1) and A3 (2), were isolated from the ΔdtlA mutant strain of marine-derived Streptomyces youssoufiensis OUC6819. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses, and their absolute configurations were determined by combination of the long-range NOE-based ¹H-¹H distance measurements and ECD calculations. Compounds 1 and 2 exhibited moderate growth inhibition against multi-drug-resistant Enterococcus faecalis CCARM 5172 with an MIC value of 22.2 μM.

Keywords: antibiotic; benzoic polyene acid; cinnamoyl lipid; marine-derived Streptomyces; multi-drug-resistant.

MeSH terms

Anti-Bacterial Agents* / pharmacology
Lipids / pharmacology
Magnetic Resonance Spectroscopy
Molecular Structure
Streptomyces* / chemistry
Streptomyces* / genetics

Substances

Anti-Bacterial Agents
Lipids

Grants and funding

This research was funded by the National Natural Science Foundation of China (NSFC) under grants U1706206, 32070054, 82073720, 81991525, and 31570032, the National Key R&D Program of China (2019YFC0312501), and the Foundation of Guangdong Key Laboratory of Marine Materia Medica (LMM2020-3).