Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts

Wenjun Liu; Changkun Li; Bohai Li; Qingxiang Shang; Zhe Han; Yuan Zhang; Xiufang Liu; Hui Fan; Jiachao Zhang; Yongfu Chen; Heping Zhang

doi:10.1016/j.isci.2022.104472

Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts

iScience. 2022 May 26;25(7):104472. doi: 10.1016/j.isci.2022.104472. eCollection 2022 Jul 15.

Authors

Wenjun Liu^{1

2}, Changkun Li¹, Bohai Li¹, Qingxiang Shang¹, Zhe Han³, Yuan Zhang¹, Xiufang Liu¹, Hui Fan¹, Jiachao Zhang³, Yongfu Chen¹, Heping Zhang¹

Affiliations

¹ Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education P. R. C., Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs China, Inner Mongolia Agricultural University, Hohhot 010018, China.
² Jiangzhong Pharmaceutical Co., Ltd, No.1 Zhaoxian Road, Wanli District, Jiangxi Province 330000, China.
³ School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, Haikou 570228 Hainan, China.

Abstract

Multiple pesticide residue accumulations increase the probability of chronic metabolic diseases in humans. Thus, we applied multi-omics techniques to reveal how the gut microbiome responded to pesticide exposure. Then, we explored how probiotic Lactiplantibacillus plantarum P9 (P9) consumption impacted the gut microbiota and immune factors after high pesticide exposure. Multi-omics results indicated frequent exposure to pesticides did not alter the composition of the intestinal microbiota, but it did increase the abundance of Lipopolysaccharide in the gut, which might contribute to chronic inflammation. Supplementation with P9 maintained the homeostasis of the gut microbiota and reduced the abundance of pathogens in the high pesticide-exposed subjects. By detecting metabolites, we observed uridine and 5-oxoproline concentrations increased significantly after P9 consumption. Furthermore, P9 alleviated immune factors disorder and promoted pesticide residue excretion. Our findings provide new insights into the application of probiotics for pesticide detoxification, and suggest probiotics as daily supplements for pesticide exposure prevention.

Keywords: Biological sciences; Microbiology; omics.