Introduction:Vector-borne diseases are infections caused by parasites, viruses and bacteria and transmitted by vectors, which are usually insects. A greater risk of diseases such as dengue, malaria, seasonal influenza, leptospirosis, chikungunya, enteric fever, etc co-exist in COVID-19 cases. This poses challenges in clinical and laboratory diagnosis of COVID-19, which may affect clinical management and patient outcomes. Methodology: Several databases, including PubMed, Scopus, DOAJ, and EMBASE, were reviewed using the keywords vector-borne infections in India amidst COVID-19 pandemic. A total of 23 articles and WHO and National website for vector-borne diseases was found. Review:For many decades, vector-borne diseases have been a major health burden for both underdeveloped and developing countries, including India. With better preparedness, the threat of climate change on vector-borne diseases may be negated. Rains during monsoon increase not only the risk of vector-borne diseases such as malaria, dengue, chikungunya but also that of food- and water-borne diseases as well as other skin infections. A greater risk of diseases such as dengue, malaria, seasonal influenza, leptospirosis, chikungunya, enteric fever, etc co-exists in COVID-19 cases. This poses challenges in clinical and laboratory diagnosis of COVID-19, which may affect clinical management and patient outcomes (3). Amidst the COVID-19 pandemic, a sudden outbreak of Zika virus infection was reported at the beginning of July 2021 in the districts of Kerala, from where it started, spreading to the neighboring states of Tamil Nadu and Kerala, India. Conclusions:With better preparedness, the threat of climate change on vector-borne diseases may be negated. Designing and strengthening an intervention strategy for environmental sanitation, regular cleaning of living houses, and keeping personal hygiene shall be considered. Risk assessment is crucial to optimize surveillance, preventative measures (vector control), and resource allocation (medical supplies).