An adaptive platform trial for evaluating treatments in patients with life-threatening hemorrhage from traumatic injuries: Rationale and proposal

Affiliations

• ¹ Department of Emergency Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
• ² Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
• ³ Berry Consultants, LLC, Austin, Texas, USA.
• ⁴ Division of Trauma, Critical Care & Acute Care Surgery, Department of Surgery, Oregon Health & Science University, Portland, Oregon, USA.
• ⁵ Joint Trauma System, Defense Health Agency, Joint Base San Antonio Fort Sam Houston, San Antonio, Texas, USA.
• ⁶ Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
• ⁷ Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
• ⁸ Department of Emergency Medicine, The Ohio State University, Columbus, Ohio, USA.
• ⁹ Center for Injury Science, University of Alabama at Birmingham, Birmingham, Alabama, USA.
• ¹⁰ Division of Trauma & Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
• ¹¹ Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA.
• ¹² Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
• ¹³ Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA.