Palladium-Catalyzed Preparation of N-Substituted Benz[ c, d]indol-2-imines and N-Substituted Amino-1-naphthylamides

Abstract

Here, we report a novel and facile protocol for the synthesis of benz[c,d]indol-2-imines via palladium-catalyzed C-C and C-N coupling of 8-halo-1-naphthylamines with isocyanides in a single step. The reaction features broad substrate scopes and mild conditions, providing an efficient alternative for the construction of antiproliferative agents and BET bromodomain inhibitors. If 0.1 mL of H₂O was added to this reaction, the N-substituted amino-1-naphthylamides could be obtained easily.