Backdoor attack intends to embed hidden backdoors into deep neural networks (DNNs), so that the attacked models perform well on benign samples, whereas their predictions will be maliciously changed if the hidden backdoor is activated by attacker-specified triggers. This threat could happen when the training process is not fully controlled, such as training on third-party datasets or adopting third-party models, which poses a new and realistic threat. Although backdoor learning is an emerging and rapidly growing research area, there is still no comprehensive and timely review of it. In this article, we present the first comprehensive survey of this realm. We summarize and categorize existing backdoor attacks and defenses based on their characteristics, and provide a unified framework for analyzing poisoning-based backdoor attacks. Besides, we also analyze the relation between backdoor attacks and relevant fields (i.e., adversarial attacks and data poisoning), and summarize widely adopted benchmark datasets. Finally, we briefly outline certain future research directions relying upon reviewed works. A curated list of backdoor-related resources is also available at https://github.com/THUYimingLi/backdoor-learning-resources.