Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis

Gabriela Fonseca-Souza; Luiza Becker de Oliveira; Letícia Maira Wambier; Rafaela Scariot; Juliana Feltrin-Souza

doi:10.1007/s00784-022-04540-8

Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis

Clin Oral Investig. 2022 Aug;26(8):5089-5103. doi: 10.1007/s00784-022-04540-8. Epub 2022 Jun 21.

Authors

Gabriela Fonseca-Souza¹, Luiza Becker de Oliveira¹, Letícia Maira Wambier², Rafaela Scariot¹, Juliana Feltrin-Souza³

Affiliations

¹ Department of Stomatology, Universidade Federal Do Paraná, Setor de Ciências da Saúde, Av. Prefeito Lothário Meissner 632, Curitiba, State of Paraná, 80210-17080210-170, Brazil.
² School of Health and Biological Sciences, Universidade Positivo, Street Prof. Pedro Viriato Parigot de Souza 5300, Curitiba, PR, 81280-330, Brazil.
³ Department of Stomatology, Universidade Federal Do Paraná, Setor de Ciências da Saúde, Av. Prefeito Lothário Meissner 632, Curitiba, State of Paraná, 80210-17080210-170, Brazil. julianafeltrin1@gmail.com.

PMID: 35729285
DOI: 10.1007/s00784-022-04540-8

Abstract

Objective: To evaluate the association between orofacial clefts (OFC) and tooth abnormalities (TA).

Methods: We searched PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and BBO, and in the gray literature and selected observational studies that evaluated the association between TA and OFC. The risk of bias was analyzed using the Newcastle-Ottawa Scale. A random-effects meta-analysis was performed comparing the presence and absence of OFC, cleft type-cleft palate (CP) and cleft lip with or without palate (CL/P)-and cleft laterality-unilateral and bilateral. The certainty of evidence was evaluated using the GRADE approach.

Results: A total of 99 studies were included in the qualitative analysis, and 37 were included in the meta-analysis. Only four studies were classified as low risk of bias. Significant associations were observed between the presence of OFC and tooth agenesis (OR = 19.46; 95%CI = 4.99-75.96), supernumerary teeth (OR = 4.04; 95%CI = 1.26-12.99), developmental defects of enamel (OR = 3.15; 95%CI = 1.28-7.80), microdontia (OR = 15.57; 95%CI = 1.06-228.51), and taurodontism (OR = 1.74; 95%CI = 1.74-2.86). Individuals with CP had a lower frequency of supernumerary teeth (OR = 0.22; 95%CI = 0.08-0.64), peg-shaped tooth (OR = 0.31; 95%CI = 0.12-0.80), and morphological TA (OR = 0.13; 95%CI = 0.04-0.45) than individuals with CL/P. No TA was significantly associated with cleft laterality (p > 0.05). The quality of the evidence was very low in all analyses.

Conclusion: Individuals with OFC had a higher frequency of TA than those without OFC. Individuals with CP had a lower frequency of TA than individuals with CL/P. No TA was associated to cleft laterality.

Clinical relevance: Help to identify the treatment needs of individuals affected by OFC, improving the services provided to this population.

Keywords: Cleft lip; Cleft palate; Congenital abnormalities; Craniofacial abnormalities; Tooth abnormalities.

Publication types

Meta-Analysis
Review
Systematic Review

MeSH terms

Cleft Lip* / complications
Cleft Lip* / epidemiology
Cleft Palate* / complications
Cleft Palate* / epidemiology
Humans
Tooth Abnormalities* / complications
Tooth Abnormalities* / epidemiology
Tooth, Supernumerary* / complications