Innate immune responses against the fungal pathogen Candida auris

Yuanyuan Wang; Yun Zou; Xiaoqing Chen; Hao Li; Zhe Yin; Baocai Zhang; Yongbin Xu; Yiquan Zhang; Rulin Zhang; Xinhua Huang; Wenhui Yang; Chaoyue Xu; Tong Jiang; Qinyu Tang; Zili Zhou; Ying Ji; Yingqi Liu; Lingfei Hu; Jia Zhou; Yao Zhou; Jingjun Zhao; Ningning Liu; Guanghua Huang; Haishuang Chang; Wenxia Fang; Changbin Chen; Dongsheng Zhou

doi:10.1038/s41467-022-31201-x

Innate immune responses against the fungal pathogen Candida auris

Nat Commun. 2022 Jun 21;13(1):3553. doi: 10.1038/s41467-022-31201-x.

Authors

Yuanyuan Wang^#^{1

2

3}, Yun Zou^#^{1

2

3}, Xiaoqing Chen^{1

2}, Hao Li⁴, Zhe Yin⁵, Baocai Zhang⁶, Yongbin Xu⁷, Yiquan Zhang⁸, Rulin Zhang⁹, Xinhua Huang¹, Wenhui Yang⁵, Chaoyue Xu^{1

3

10}, Tong Jiang^{1

2}, Qinyu Tang¹¹, Zili Zhou¹, Ying Ji^{1

2}, Yingqi Liu¹², Lingfei Hu⁵, Jia Zhou¹³, Yao Zhou¹⁴, Jingjun Zhao¹¹, Ningning Liu¹³, Guanghua Huang¹⁵, Haishuang Chang¹⁶, Wenxia Fang¹⁴, Changbin Chen^{17

18}, Dongsheng Zhou¹⁹

Affiliations

¹ The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ Nanjing Advanced Academy of Life and Health, Nanjing, 211135, China.
⁴ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
⁵ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.
⁶ State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
⁷ Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
⁸ Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu, China.
⁹ Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 20008, China.
¹⁰ College of Life Science, Shanghai University, Shanghai, China.
¹¹ Department of Dermatology, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China.
¹² School of Basic Medicine, Gannan Medical University, Ganzhou, China.
¹³ Center for Single-Cell Omics, School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, China.
¹⁴ National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning, 530007, Guangxi, China.
¹⁵ Department of Infectious Disease, Huashan Hospital and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
¹⁶ Shanghai Institute of Precision Medicine, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
¹⁷ The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China. cbchen@ips.ac.cn.
¹⁸ Nanjing Advanced Academy of Life and Health, Nanjing, 211135, China. cbchen@ips.ac.cn.
¹⁹ State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. zhouds@bmi.ac.cn.

^# Contributed equally.

Abstract

Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth. Here, we compare the innate immune responses induced by C. auris BJCA001 and Candida albicans SC5314 in vitro and in vivo. Our results indicate that C. auris BJCA001 appears to be less immunoinflammatory than C. albicans SC5314, and this differential response correlates with structural features of the cell wall.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / pharmacology
Candida albicans
Candida auris
Candida*
Candidiasis* / microbiology
Humans
Immunity, Innate
Microbial Sensitivity Tests

Substances

Antifungal Agents