Integrins are double-edged swords in pulmonary infectious diseases

Ye Yao; Huijun Liu; Lin Yuan; Xizi Du; Yu Yang; Kai Zhou; Xinyu Wu; Ling Qin; Ming Yang; Yang Xiang; Xiangping Qu; Xiaoqun Qin; Chi Liu

doi:10.1016/j.biopha.2022.113300

Integrins are double-edged swords in pulmonary infectious diseases

Biomed Pharmacother. 2022 Sep:153:113300. doi: 10.1016/j.biopha.2022.113300. Epub 2022 Jun 18.

Authors

Ye Yao¹, Huijun Liu², Lin Yuan², Xizi Du², Yu Yang², Kai Zhou², Xinyu Wu², Ling Qin³, Ming Yang⁴, Yang Xiang², Xiangping Qu², Xiaoqun Qin², Chi Liu⁵

Affiliations

¹ Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China.
² Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China.
³ Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW, Australia.
⁵ Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Research Center of China-Africa Infectious Diseases, Xiangya School of Medicine Central South University, Changsha, Hunan, China. Electronic address: Liu.chi@csu.edu.cn.

PMID: 35728353
DOI: 10.1016/j.biopha.2022.113300

Abstract

Integrins are an important family of adhesion molecules that are widely distributed on immune cells in the lungs. Of note, accumulating evidences have shown that integrins are double-edged swords in pulmonary infectious diseases. On one hand, integrins promote the migration of immune cells to remove the invaded pathogens in the infected lungs. However, on the other hand, integrins also act as the targets for pathogens to escape from host immune system, which is a potential factor leading to further tissue damage. Thus, the innovative therapeutic strategies based on integrins has inspired well-founded hopes to treat pulmonary infectious diseases. In this review, we illustrate the involvement of integrins in pulmonary infectious diseases, and further discuss the innovative therapeutic targets based on integrins.

Keywords: Immune cells; Integrins; Pathogen; Pulmonary infectious diseases.

Publication types

Review

MeSH terms

Cell Adhesion Molecules
Communicable Diseases*
Humans
Integrins*
Lung

Substances

Cell Adhesion Molecules
Integrins