About 10 %-12 % of couples in the world suffer from infertility, and immunological factors are being paid more and more attention. Attempts to induce peripheral immune tolerance in pregnant women by injecting husband cells have been widely promoted, but ultimately proved unsuccessful. Over the past two decades, our understanding of how the immune system is involved in gametogenesis and embryonic development, especially in early pregnancy, has undergone a major shift, going from the periphery to the local area of reproductive tissue. However, a holistic overview of immune responses in reproductive organs and tissues is currently lacking. Here, we further highlight the importance of regional immunity research for understanding reproductive health by reviewing the research mileage of the testis, ovary, and uterine immune microenvironment. We propose the concept of "reproductive immune microenvironment (RIM)" by summarizing the common features and basic functions of the tissue microenvironment in which immune cells reside, including the interstitial space of the testis, the ovarian stroma and the endometrium. The establishment of the concept of RIM not only focuses on the comprehensive description of the immune response in reproductive tissues, but also provides a macroscopic perspective for a deeper understanding of the immune etiology of reproductive system-related diseases.
Keywords: Endometrium; Innate immunity; Ovarian stroma; Reproductive immune microenvironment; Testicular interstitial space.
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