Azoospermia: Is it worth waiting for the confirmation of the semen abnormality to start an infertility assessment?

Andrologia. 2022 Sep;54(8):e14487. doi: 10.1111/and.14487. Epub 2022 Jun 20.

Abstract

Azoospermia is found in about 1% of men in the general population and in about 10%-15% of infertile men. Upon discovery of semen analysis abnormality, another test must be performed after an interval of 3 months before any other infertility work-up. This research aimed at evaluating the benefit of waiting for the control test. This retrospective monocentric descriptive study was carried out in the fertility center of the University Hospital of Saint Etienne. All consecutive azoospermic patients diagnosed between January, 2012 and December, 2019 were included. For each patient, two consecutive semen analyses performed 3 months apart were studied. The main focas was on patients whose second semen analysis would have modified the infertility work-up. Amongst the 172 cases under study, the second semen analysis revealed the presence of sperm for three men. Only one of these 3 modified semen analyses was normal. In the observed azoospermic population, sperm was found on the second test in 1.7%. An infertility assessment is necessary after the discovery of azoospermia in the first semen analysis in 99.5%. These results suggest that it is useless to wait three stressful months before starting an infertility assessment for azoospermic population.

Keywords: azoospermia; infertility; semen analysis.

MeSH terms

  • Azoospermia* / diagnosis
  • Humans
  • Infertility, Male* / diagnosis
  • Male
  • Retrospective Studies
  • Semen
  • Semen Analysis
  • Spermatozoa