Sodium alginate based drug delivery in management of breast cancer

Mohammad Arshad Javed Shaikh; Khalid Saad Alharbi; Waleed Hassan Almalki; Syed Sarim Imam; Mohammed Albratty; Abdulkarim M Meraya; Sami I Alzarea; Imran Kazmi; Fahad A Al-Abbasi; Obaid Afzal; Abdulmalik Saleh Alfawaz Altamimi; Yogendra Singh; Sachin Kumar Singh; Kamal Dua; Gaurav Gupta

doi:10.1016/j.carbpol.2022.119689

Sodium alginate based drug delivery in management of breast cancer

Carbohydr Polym. 2022 Sep 15:292:119689. doi: 10.1016/j.carbpol.2022.119689. Epub 2022 Jun 2.

Authors

Affiliations

¹ School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India; Department of Pharmacy, TPCT's College of Engineering, Osmanabad, Maharashtra, India.
² Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia.
³ Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
⁴ Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
⁵ Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
⁶ Pharmacy Practice Research Unit, Department of Clinical Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
⁷ Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
⁸ Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj 11942, Saudi Arabia.
⁹ Department of Pharmacology, Maharishi Arvind College of Pharmacy, Ambabari Circle, Ambabari, Jaipur 302023, India.
¹⁰ School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.
¹¹ Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia.
¹² School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302017, Mahal Road, Jaipur, India; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India. Electronic address: gauravpharma25@gmail.com.

PMID: 35725179
DOI: 10.1016/j.carbpol.2022.119689

Abstract

Among women, breast cancer (B·C.) is a common form of cancer that can strike either developed or developing countries. In addition to pregnancy-related variables, hormone therapy lifestyle factors (e.g., physical inactivity, smoking, and alcohol use) may all influence the progression of B·C. The creation of anti-B·C. medication carriers with better stability, controlled and targeted administration, and the goal of minimizing unwanted effects has taken a lot of time and effort. Naturally generated biopolymers-based pharmaceutical delivery techniques have attracted attention for their potential use in treating B·C. It's been shown that natural polymers can deliver high medication concentrations to the desired place and provide prolonged release of pharmaceuticals useful in treating B.C. Alginate is one of the most commonly used drug carriers for delayed and targeted release. In present review will discuss the utilization of sodium alginate as an carrier of anticancer drug, such as paclitaxel, doxorubicin, tamoxifen, curcumin, and others.

Keywords: Breast cancer; Drug carrier; Polysaccharides; Signaling pathway; Sodium alginate.

Publication types

Review

MeSH terms

Alginates*
Breast Neoplasms* / drug therapy
Doxorubicin / therapeutic use
Drug Carriers
Drug Delivery Systems
Female
Humans

Substances

Alginates
Drug Carriers
Doxorubicin