Body mass index and postoperative mortality in patients undergoing coronary artery bypass graft surgery plus valve replacement: a retrospective cohort study

Chun Dai; Hongbo Xu; Tianshu Chu; Boyang Cao; Jianjun Ge

doi:10.7717/peerj.13601

Body mass index and postoperative mortality in patients undergoing coronary artery bypass graft surgery plus valve replacement: a retrospective cohort study

PeerJ. 2022 Jun 14:10:e13601. doi: 10.7717/peerj.13601. eCollection 2022.

Authors

Chun Dai^#^{1

2}, Hongbo Xu^#^{1

2}, Tianshu Chu³, Boyang Cao³, Jianjun Ge³

Affiliations

¹ The Lu'an Hospital Affiliated to Anhui Medical University, Lu'an, Anhui, China.
² The Lu'an People's Hospital, Lu'an, Anhui, China.
³ The First Affiliated Hospital of USTC, Hefei, China.

^# Contributed equally.

Abstract

Background: The relationship between body mass index (BMI) and postoperative mortality in patients who undergo coronary artery bypass graft (CABG) surgery plus valve replacement is uncertain. We aimed to investigate the association between body mass index (BMI) and postoperative mortality among patients who simultaneously underwent both CABG surgery plus valve replacement.

Methods: We retrospectively analyzed 1976 patients who underwent CABG surgery at our hospital between January 2017 and April 2021, including 202 patients who underwent valve replacement surgery during the same period. We analyzed the relationship between BMI and postoperative mortality. The relationship between BMI and postoperative mortality was assessed using smooth curve fitting and a Multiple logistic regression model.

Results: The results of smoothing curve fitting showed that BMI and postoperative mortality had a non-linear relationship, and the resulting curve exhibited a two-stage change and a breakpoint. Postoperative mortality is higher in patients that have a body mass index above 25 kg/m² compared to patients having a body mass index between 18 and 25 kg/m².

Conclusions: Our study found a non-linear relationship between BMI and postoperative mortality in patients undergoing CABG plus valve replacement after adjusting for potential confounders. The causal relationship between BMI and postoperative mortality still requires further investigations.

Keywords: BMI; Cardiac disease; Coronary artery bypass graft; Mortality; Valve replacement.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Body Mass Index
Coronary Artery Bypass* / adverse effects
Heart Valve Prosthesis Implantation* / adverse effects
Humans
Retrospective Studies

Grants and funding

This work was supported by the National Natural Science Foundation of China (grant numbers NSFC 81470530-JG), Natural Science Foundation of Anhui Province (2008085MH240) and Major Science and Technology Project of Anhui Province (18030801132). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.