The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

Jieyao Ma; Kailin Li; Silin Shi; Jian Li; Sunv Tang; LiangHong Liu

doi:10.3389/fphar.2022.922488

The Application of UHPLC-HRMS for Quality Control of Traditional Chinese Medicine

Front Pharmacol. 2022 Jun 2:13:922488. doi: 10.3389/fphar.2022.922488. eCollection 2022.

Authors

Jieyao Ma^{1

2}, Kailin Li¹, Silin Shi¹, Jian Li¹, Sunv Tang¹, LiangHong Liu^{1

2}

Affiliations

¹ School of Pharmaceutical Sciences, Hunan Province Key Laboratory for Antibody-Based Drug and Intelligent Delivery System, Hunan University of Medicine, Huaihua, China.
² Hunan Provincial Key Laboratory of Dong Medicine, Hunan University of Medicine, Huaihua, China.

Abstract

UHPLC-HRMS (ultra-high-performance liquid chromatography-high resolution mass spectrometry) is a new technique that unifies the application of UHPLC with HRMS. Because of the high sensitivity and good separation ability of UHPLC and the sensitivity of HRMS, this technique has been widely used for structure identification, quantitative determination, fingerprint analysis, and elucidation of the mechanisms of action of traditional Chinese medicines (TCMs) in recent years. This review mainly outlines the advantages of using UHPLC-HRMS and provides a survey of the research advances on UHPLC-HRMS for the quality control of TCMs.

Keywords: UHPLC-HRMS; fingerprint analysis; quality control; structure identification; traditional Chinese medicine (TCM).

Publication types

Review