Analysis of Risk Factors of Soft Tissue Bleeding in COVID-19 Patients: A Point of View After Two Years of Pandemic

Eliodoro Faiella; Gennaro Castiello; Domiziana Santucci; Giuseppina Pacella; Caterina Bernetti; Moises Muley Villamu; Raffaele Antonelli Incalzi; Bruno Beomonte Zobel; Carlo Cosimo Quattrocchi; Rosario Francesco Grasso

doi:10.14740/jocmr4708

Analysis of Risk Factors of Soft Tissue Bleeding in COVID-19 Patients: A Point of View After Two Years of Pandemic

J Clin Med Res. 2022 May;14(5):188-195. doi: 10.14740/jocmr4708. Epub 2022 May 31.

Affiliations

¹ Department of Radiology, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.
² Department of Radiology, Sant'Anna Hospital, Via Ravona, 22042 San Fermo della Battaglia CO, Italy.
³ Department of Geriatrics, Campus Bio-Medico University, Via Alvaro del Portillo, 21-00128 Rome, Italy.

Abstract

Background: The aim of the study was to analyze the relationship between patient characteristics, including anagraphic and laboratoristic data and amount of adipose tissue measured in computed tomography (CT) scans in coronavirus disease 2019 (COVID-19) patients, and incidence of soft tissue bleeding requiring medical and/or interventional radiology management.

Methods: A total of 132 patients hospitalized for COVID-19 pathology from October 2020 to May 2021 were included in the study and divided into two groups: a bleeding group of 70 cases with soft tissue bleeding occurring during hospitalization, and a control group of 62 hospitalized COVID-19 patients without bleeding events. In the bleeding group, two subgroups were considered: an embolization group including soft tissue bleeding cases requiring interventional radiology with transarterial embolization (TAE) (16/70; 22.9%) and a non-embolization group, clinically managed without TAE (54/70; 77.1%). Demographics and clinical data, visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area measured on CT images and VAT/SAT ratio were compared between bleeding and control groups and between embolization and non-embolization subgroups.

Results: Bleeding and control groups did not significantly differ for sex distribution, COVID-19, platelet (PLT) count, international normalized ratio (INR), SAT area, VAT area, and VAT/SAT ratio. Embolization and non-embolization groups did not significantly differ for age, COVID-19, PLT count, INR, SAT area, and VAT/SAT ratio. Bleeding group had lower body mass index (BMI) than control group as well as embolization group compared to non-embolization group. A statistically significant difference was observed between embolization and non-embolization groups for VAT area, with smaller values in embolization group (mean difference: 64.2 cm², 95% confidence interval: 8.3 - 120.1; P < 0.05).

Conclusion: Soft tissue bleeding in COVID-19 is more frequent and severe in patients with low amount of VAT, demonstrating that fat mass may have a containing function on bleeding, limiting its progression in surrounding structures. There are some other factors that influence the risk of bleeding, such as age, thromboprophylaxis therapy and BMI.

Keywords: Embolization; SARS-CoV-2 infection; Soft tissue bleeding; Visceral fat.