[Meta-analysis of Shenqi Jiangtang Granules combined with western medicine on adverse pregnancy outcomes in women with gestational diabetes mellitus]

Li-Jun Zhang; Xiao-Qiang Hu; Jing-Jing Yu; Ying Wang; Jia-Wei Zhang; Xian-Rong Xu; Jun Yang

doi:10.19540/j.cnki.cjcmm.20220218.501

[Meta-analysis of Shenqi Jiangtang Granules combined with western medicine on adverse pregnancy outcomes in women with gestational diabetes mellitus]

Zhongguo Zhong Yao Za Zhi. 2022 May;47(10):2811-2818. doi: 10.19540/j.cnki.cjcmm.20220218.501.

[Article in Chinese]

Authors

Li-Jun Zhang¹, Xiao-Qiang Hu¹, Jing-Jing Yu¹, Ying Wang¹, Jia-Wei Zhang¹, Xian-Rong Xu¹, Jun Yang²

Affiliations

¹ Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University Hangzhou 311121, China.
² Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University Hangzhou 311121, China Center for Uterine Cancer Diagnosis and Therapy Research, the Affiliated Women's Hospital, Zhejiang University Hangzhou 310006, China.

PMID: 35718501
DOI: 10.19540/j.cnki.cjcmm.20220218.501

Abstract

The present study evaluated the effect of Shenqi Jiangtang Granules(SJG) combined with western medicine on the adverse pregnancy outcomes in women with gestational diabetes mellitus(GDM). PubMed, Web of Science, CNKI, Wanfang, and VIP were searched for clinical randomized controlled trials(RCTs) of SJG combined with western medicine against GDM. The included RCTs were assessed for risks using the assessment criteria recommended by the Cochrane handbook for systematic reviews of interventions. Meta-analysis was performed using Stata 12.0 and RevMan 5.3. Nineteen RCTs were included, with 1 647 patients involved, including 824 cases treated with western medicine alone, and 823 cases treated with SJG combined with western medicine. The course of treatment ranged from 2 to 12 weeks. As revealed by Meta-analysis results, compared with western medicine treatment alone, SJG combined with western medicine could reduce the incidence of postpartum hemorrhage(OR=0.23, 95%CI[0.10, 0.53], P=0.000 6), gestational hypertension(OR=0.24, 95%CI[0.13, 0.45], P<0.000 01), polyhydramnios(OR=0.24, 95%CI[0.12, 0.45], P<0.000 1), premature rupture of membranes(OR=0.20, 95%CI[0.09, 0.45], P<0.000 1), cesarean section(OR=0.40, 95%CI[0.29, 0.55], P<0.000 01), macrosomia(OR=0.19, 95%CI[0.08, 0.47], P<0.000 3), neonatal asphyxia(OR=0.22, 95%CI[0.12, 0.40], P<0.000 01), premature delivery(OR=0.19, 95%CI[0.12, 0.30], P<0.000 01), proteinuria(OR=0.19, 95%CI[0.06, 0.58], P=0.004) and hypoglycemia(OR=0.28, 95%CI[0.16, 0.50], P<0.000 1). The funnel plots and Egger's test showed that except macrosomia, there was no significant publication bias in the results of other indicators. Therefore, as indicated by the findings, SJG combined with western medicine can reduce the incidence of adverse pregnancy outcomes in GDM patients. However, due to the uneven quality of the included trials, the clinical application of this protocol requires caution.

Keywords: Meta-analysis; Shenqi Jiangtang Granules(SJG); adverse pregnancy outcome; curative effect; gestational diabetes mellitus(GDM).

Publication types

Meta-Analysis

MeSH terms

Cesarean Section
Diabetes, Gestational* / drug therapy
Drugs, Chinese Herbal
Female
Fetal Macrosomia
Humans
Infant, Newborn
Pregnancy
Pregnancy Outcome
Systematic Reviews as Topic

Substances

Drugs, Chinese Herbal
shenqi