Recent progress in liquid embolic agents

Giho Ko; Jin Woo Choi; Nohyun Lee; Dokyoon Kim; Taeghwan Hyeon; Hyo-Cheol Kim

doi:10.1016/j.biomaterials.2022.121634

Recent progress in liquid embolic agents

Biomaterials. 2022 Aug:287:121634. doi: 10.1016/j.biomaterials.2022.121634. Epub 2022 Jun 13.

Authors

Giho Ko¹, Jin Woo Choi², Nohyun Lee³, Dokyoon Kim⁴, Taeghwan Hyeon⁵, Hyo-Cheol Kim⁶

Affiliations

¹ Center for Nanoparticle Research, Institute for Basic Spegcience (IBS), Seoul 08826, Republic of Korea; School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea.
² Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
³ School of Advanced Materials Engineering, Kookmin University, Seoul 02707, Republic of Korea.
⁴ Department of Bionano Engineering and Bionanotechnology, Hanyang University, Ansan 15588, Republic of Korea. Electronic address: kimdk@hanyang.ac.kr.
⁵ Center for Nanoparticle Research, Institute for Basic Spegcience (IBS), Seoul 08826, Republic of Korea; School of Chemical and Biological Engineering, and Institute of Chemical Processes, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: thyeon@snu.ac.kr.
⁶ Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address: radioembolization@snu.ac.kr.

PMID: 35716628
DOI: 10.1016/j.biomaterials.2022.121634

Abstract

Vascular embolization is a non-surgical procedure used to treat diseases or morbid conditions related to blood vessels, such as bleeding, arteriovenous malformation, aneurysm, and hypervascular tumors, through the intentional occlusion of blood vessels. Among various types of embolic agents that have been applied, liquid embolic agents are gaining an increasing amount of attention owing to their advantages in distal infiltration into regions where solid embolic agents cannot reach, enabling more extensive embolization. Meanwhile, recent advances in biomaterials and technologies have also contributed to the development of novel liquid embolic agents that can resolve the challenges faced while using the existing embolic materials. In this review, we briefly summarize the clinically used embolic agents and their applications, and then present selected research results that overcome the limitations of the embolic agents in use. Through this review, we suggest the required properties of liquid embolic agents that ensure efficacy, which can replace the existing agents, providing directions for the future development in this field.

Keywords: Embolization; Liquid embolic agents; Medical devices; Minimally invasive procedures.

Publication types

Review