What Have We Learned in the Last 20 Years About CRT Non-Responders?

Peregrine G Green; Neil Herring; Timothy R Betts

doi:10.1016/j.ccep.2021.12.019

What Have We Learned in the Last 20 Years About CRT Non-Responders?

Card Electrophysiol Clin. 2022 Jun;14(2):283-296. doi: 10.1016/j.ccep.2021.12.019.

Authors

Peregrine G Green¹, Neil Herring², Timothy R Betts³

Affiliations

¹ Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK; Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Level 0 John Radcliffe Hospital, Oxford, OX3 9DU, UK; Oxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.
² Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK; Oxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.
³ Oxford Heart Centre, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK; Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address: tim.betts@ouh.nhs.uk.

PMID: 35715086
DOI: 10.1016/j.ccep.2021.12.019

Abstract

Although cardiac resynchronization therapy (CRT) has become well established in the treatment of heart failure, the management of patients who do not respond after CRT remains a key challenge. This review will summarize what we have learned about non-responders over the last 20 years and discuss methods for optimizing response, including the introduction of novel therapies.

Keywords: Biventricular pacing; Cardiac resynchronization therapy; Heart failure; Non-Responders; Optimization.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cardiac Resynchronization Therapy* / methods
Heart Failure* / etiology
Heart Failure* / therapy
Humans
Treatment Outcome

Abstract

Publication types

MeSH terms

Grants and funding