Multisite Left Ventricular Pacing in Cardiac Resynchronization Therapy

Sandeep K Jain; Samir Saba

doi:10.1016/j.ccep.2021.12.003

Multisite Left Ventricular Pacing in Cardiac Resynchronization Therapy

Card Electrophysiol Clin. 2022 Jun;14(2):253-261. doi: 10.1016/j.ccep.2021.12.003. Epub 2022 May 24.

Authors

Sandeep K Jain¹, Samir Saba²

Affiliations

¹ Cardiac Electrophysiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, South Tower E352.6, Pittsburgh, PA 15213, USA.
² Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, 200 Lothrop Street, South Tower E355.6, Pittsburgh, PA 15213, USA. Electronic address: sabas@upmc.edu.

PMID: 35715083
DOI: 10.1016/j.ccep.2021.12.003

Abstract

Cardiac resynchronization therapy (CRT) is an established treatment of patients with heart failure with reduced ejection fraction and prolonged ventricular depolarization on surface electrocardiogram. Although patients' characteristics, such as their type of cardiomyopathy and the morphology and width of their baseline QRS complex, have been associated with CRT response, these features are not modifiable. Left ventricular multisite pacing has been proposed and tested as a tool to improve response to CRT and positively impact patient outcomes. This article reviews the published literature on left ventricular multisite pacing, with focus on the results of recently presented or published clinical trials.

Keywords: Cardiac resynchronization therapy; Heart failure; Multipoint pacing; Multisite pacing; Response.

Publication types

Review

MeSH terms

Cardiac Resynchronization Therapy* / methods
Heart Failure* / therapy
Heart Ventricles
Humans
Treatment Outcome
Ventricular Dysfunction, Left* / therapy