Role of Electrical Delay in Cardiac Resynchronization Therapy Response

Zain S Gowani; Brett Tomashitis; Chau N Vo; Michael E Field; Michael R Gold

doi:10.1016/j.ccep.2021.12.013

Role of Electrical Delay in Cardiac Resynchronization Therapy Response

Card Electrophysiol Clin. 2022 Jun;14(2):233-241. doi: 10.1016/j.ccep.2021.12.013.

Authors

Zain S Gowani¹, Brett Tomashitis¹, Chau N Vo¹, Michael E Field¹, Michael R Gold²

Affiliations

¹ Department of Medicine, Medical University of South Carolina, 25 Courtenay Drive, MS-492, Charleston, SC 29425, USA.
² Department of Medicine, Medical University of South Carolina, 25 Courtenay Drive, MS-492, Charleston, SC 29425, USA. Electronic address: goldmr@musc.edu.

PMID: 35715081
DOI: 10.1016/j.ccep.2021.12.013

Abstract

Traditionally, left ventricular (LV) lead position was guided by anatomic criteria of pacing from the lateral wall of the LV. However, large trials showed little effect of LV lead position on outcomes, other than noting worse outcomes with apical positions. Given the poor correlation of cardiac resynchronization therapy (CRT) outcomes with anatomically guided LV lead placement, focus shifted toward more physiologic predictors such as targeting the areas of delayed mechanical and electrical activation. Measures of left ventricular delay and interventricular delay are strong predictors of CRT response.

Keywords: Cardiac resynchronization therapy; Electrical delay; Left ventricular pacing.

Publication types

Review

MeSH terms

Cardiac Resynchronization Therapy Devices
Cardiac Resynchronization Therapy*
Heart Failure* / therapy
Heart Ventricles
Humans
Treatment Outcome