Aortic local biomechanical properties in ascending aortic aneurysms

Siyu Lin; Marie Catherine Morgant; Diana M Marín-Castrillón; Paul M Walker; Ludwig Serge Aho Glélé; Arnaud Boucher; Benoit Presles; Olivier Bouchot; Alain Lalande

doi:10.1016/j.actbio.2022.06.019

Aortic local biomechanical properties in ascending aortic aneurysms

Acta Biomater. 2022 Sep 1:149:40-50. doi: 10.1016/j.actbio.2022.06.019. Epub 2022 Jun 15.

Authors

Siyu Lin¹, Marie Catherine Morgant², Diana M Marín-Castrillón³, Paul M Walker⁴, Ludwig Serge Aho Glélé⁵, Arnaud Boucher³, Benoit Presles³, Olivier Bouchot², Alain Lalande⁴

Affiliations

¹ ImViA laboratory, University of Burgundy, Dijon, France. Electronic address: siyu.lin@u-bourgogne.fr.
² ImViA laboratory, University of Burgundy, Dijon, France; Department of Cardio-Vascular and Thoracic Surgery, University Hospital of Dijon, Dijon, France.
³ ImViA laboratory, University of Burgundy, Dijon, France.
⁴ ImViA laboratory, University of Burgundy, Dijon, France; Department of Medical Imaging, University Hospital of Dijon, Dijon, France.
⁵ Department of Epidemiology and Hygiene, University Hospital of Dijon, Dijon, France.

PMID: 35714897
DOI: 10.1016/j.actbio.2022.06.019

Abstract

Ascending aortic aneurysm (AsAA) is a high-risk cardiovascular disease with an increased incidence over years. In this study, we compared different risk factors based on the pre-failure behavior (from a biomechanical point of view) obtained ex-vivo from an equi-biaxial tensile test. A total of 100 patients (63 ± 12 years, 72 males) with AsAA replacement, were recruited. Equi-biaxial tensile tests of AsAA walls were performed on freshly sampled aortic wall tissue after ascending aortic replacement. The aneurysmal aortic walls were divided into four quadrants (medial, anterior, lateral, and posterior) and two directions (longitudinal and circumferential) were considered. The stiffness was represented by the maximum Young modulus (MYM). Based on patient information, the following subgroups were considered: age, gender, hypertension, obesity, dyslipidemia, diabetes, smoking history, aortic insufficiency, aortic stenosis, coronary artery disease, aortic diameter and aortic valve type. In general, when the aortic diameter increased, the aortic wall became thicker. In terms of the MYM, the longitudinal direction was significantly higher than that in the circumferential direction. In the multivariant analysis, the impact factors of age (p = 0.07), smoking (p = 0.05), diabetes (p = 0.03), aortic stenosis (p = 0.02), coronary artery disease (p < 10^-3), and aortic diameters (p = 0.02) were significantly influencing the MYM. There was no significant MYM difference when the patients presented arterial hypertension, dyslipidemia, obesity, or bicuspid aortic valve. To conclude, the pre-failure aortic stiffness is multi-factorial, according to our population of 100 patients with AsAA. STATEMENT OF SIGNIFICANCE: Our research on the topic of "Aortic local biomechanical properties in case of ascending aortic aneurysms" is about the biomechanical properties on one hundred aortic samples according to the aortic wall quadrants and the direction. More than ten factors and risks which may impact ascending aortic aneurysms have been studied. According to our knowledge, so far, this article involved the largest population on this topic. It will be our pleasure to share this information with all the readers.

Keywords: Ascending aortic aneurysms; Biomechanical properties; Equi-biaxial tensile test; Fresh human aorta.

MeSH terms

Aorta
Aortic Aneurysm* / etiology
Aortic Aneurysm, Thoracic*
Aortic Valve
Aortic Valve Stenosis*
Biomechanical Phenomena
Diabetes Mellitus*
Humans
Hypertension*
Male
Obesity