Common and Distinct Neural Patterns of Attention-Deficit/Hyperactivity Disorder and Borderline Personality Disorder: A Multimodal Functional and Structural Meta-analysis

Nanfang Pan; Song Wang; Kun Qin; Lei Li; Ying Chen; Xun Zhang; Han Lai; Xueling Suo; Yajing Long; Yifan Yu; Shiyu Ji; Joaquim Radua; John A Sweeney; Qiyong Gong

doi:10.1016/j.bpsc.2022.06.003

Common and Distinct Neural Patterns of Attention-Deficit/Hyperactivity Disorder and Borderline Personality Disorder: A Multimodal Functional and Structural Meta-analysis

Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 Jun;8(6):640-650. doi: 10.1016/j.bpsc.2022.06.003. Epub 2022 Jun 15.

Authors

Nanfang Pan¹, Song Wang², Kun Qin¹, Lei Li¹, Ying Chen¹, Xun Zhang¹, Han Lai¹, Xueling Suo¹, Yajing Long¹, Yifan Yu¹, Shiyu Ji¹, Joaquim Radua³, John A Sweeney⁴, Qiyong Gong⁵

Affiliations

¹ Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China; Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China.
² Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China; Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China. Electronic address: wangs_psych@163.com.
³ Imaging of Mood- and Anxiety-Related Disorders Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain; Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
⁴ Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China; Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio.
⁵ Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China; Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, China. Electronic address: qiyonggong@hmrrc.org.cn.

PMID: 35714858
DOI: 10.1016/j.bpsc.2022.06.003

Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD) have partially overlapping symptom profiles and are highly comorbid in adults. However, whether the behavioral similarities correspond to shared neurobiological substrates is not known.

Methods: An overlapping meta-analysis of 58 ADHD and 66 BPD whole-brain articles incorporating observations from 3401 adult patients and 3238 healthy participants was performed by seed-based d mapping. Brain maps were subjected to meta-analytic connectivity modeling and data-driven functional decoding analyses to identify associated neural circuit alterations and relations to behavioral dimensions.

Results: Both groups exhibited hypoactivated abnormalities in the left inferior parietal lobule, and altered clusters of the bilateral superior temporal gyrus were disjunctive in ADHD and BPD. No overlapping structural abnormalities were found. Multimodal alterations of ADHD were located in the right putamen and of BPD in the left orbitofrontal cortex.

Conclusions: The transdiagnostic neural bases of ADHD and BPD in temporoparietal circuitry may underlie overlapping problems of behavioral control, while disorder-specific substrates in frontostriatal circuitry may account for their distinguishing features in motor and emotion domains, respectively.

Keywords: Attention-deficit/hyperactivity disorder; Borderline personality disorder; Meta-analysis; Psychoradiology; Voxel-based morphometry; fMRI.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Attention Deficit Disorder with Hyperactivity*
Borderline Personality Disorder*
Brain
Brain Mapping
Frontal Lobe
Humans