TADs do not stay in the loop

Davide Michieletto; Wendy A Bickmore

doi:10.1016/j.molcel.2022.05.033

TADs do not stay in the loop

Mol Cell. 2022 Jun 16;82(12):2188-2189. doi: 10.1016/j.molcel.2022.05.033.

Authors

Davide Michieletto¹, Wendy A Bickmore²

Affiliations

¹ School of Physics and Astronomy, Peter Guthrie Tait Road, University of Edinburgh, Edinburgh, UK; MRC Human Genetics Unit, Institute of Genetics and Cancer, Crewe Road, University of Edinburgh, Edinburgh, UK. Electronic address: davide.michieletto@ed.ac.uk.
² MRC Human Genetics Unit, Institute of Genetics and Cancer, Crewe Road, University of Edinburgh, Edinburgh, UK. Electronic address: wendy.bickmore@ed.ac.uk.

PMID: 35714583
DOI: 10.1016/j.molcel.2022.05.033

Abstract

In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a "partially extruded state" and that CTCF-CTCF loops are rare.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

CCCTC-Binding Factor / genetics
Chromatin*

Substances

CCCTC-Binding Factor
Chromatin

Abstract

Publication types

MeSH terms

Substances

Grants and funding