Long term feasibility of ultraprotective lung ventilation with low-flow extracorporeal carbon dioxide removal in ARDS patients

Abstract

Purpose: To explore the feasibility of long-term application of ultraprotective ventilation with low flow ECCO₂R support in moderate-severe ARDS patients and the reduction of mechanical power (MP) compared to lung protective ventilation.

Material and methods: ARDS patients with PaO₂/FiO₂ < 200, PEEP of 10 cmH₂O, tidal volume 6 ml/Kg of predicted body weight (PBW), plateau pressure > 24 cmH₂O, MP > 17 J/min were prospectively enrolled. After 2 h tidal volume was reduced to 4-5 ml/kg, respiratory rate (RR) and PEEP were changed to maintain similar minute ventilation and mean airway pressure (MAP) to those obtained at baseline. After 2 h, ECCO₂R support was started, RR was decreased and PEEP was increased to maintain similar PaCO₂ and MAP, respectively.

Results: The only reduction of tidal volume with the increase in RR did not decrease MP. The application of low flow ECCO₂R support allowed a reduction of RR from 25 [24-30] to 11 [9-14] bpm and MP from 18 [13-23] to 8 [7-11] J/min. During the following 5 days no changes in mechanics variables and gas exchange occurred.

Conclusions: The application of low flow ECCO₂R support with ultraprotective ventilation was feasible minimizing the MP without deterioration in oxygenation in ARDS patients.

Keywords: ARDS; Extracorporeal carbon dioxide removal; Protective ventilation.