Association of variants in FABP4, FASN, SCD, SREBP1 and TCAP genes with intramuscular fat, carcass traits and body size in Chinese Qinchuan cattle

Y Y Gao; G Cheng; Z X Cheng; C Bao; T Yamada; G F Cao; S Q Bao; N M Schreurs; L S Zan; B Tong

doi:10.1016/j.meatsci.2022.108882

Association of variants in FABP4, FASN, SCD, SREBP1 and TCAP genes with intramuscular fat, carcass traits and body size in Chinese Qinchuan cattle

Meat Sci. 2022 Oct:192:108882. doi: 10.1016/j.meatsci.2022.108882. Epub 2022 Jun 9.

Authors

Y Y Gao¹, G Cheng², Z X Cheng¹, C Bao¹, T Yamada³, G F Cao⁴, S Q Bao¹, N M Schreurs⁵, L S Zan⁶, B Tong⁷

Affiliations

¹ The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China.
² National Beef Cattle Improvement Center, College of Animal Science and Technology, Northwest A & F University, Yangling 712100, China.
³ Department of Agrobiology, Faculty of Agriculture, Niigata University, Niigata 950-2181, Japan.
⁴ Department of Veterinary, Inner Mongolia Agricultural University, Hohhot 010018, China.
⁵ Animal Science, School of Agriculture and Environment, Massey University, Palmerston North 4442, New Zealand.
⁶ National Beef Cattle Improvement Center, College of Animal Science and Technology, Northwest A & F University, Yangling 712100, China. Electronic address: zanlinsen@163.com.
⁷ The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China. Electronic address: tongbin@imu.edu.cn.

PMID: 35714427
DOI: 10.1016/j.meatsci.2022.108882

Abstract

This study aimed to genotype the variants in FABP4, FASN, SCD, SREBP1 and TCAP genes, and to analyze their associations with intramuscular fat (IMF) content, carcass traits and body size in Chinese Qinchuan cattle (QC). The association studies showed that the FABP4 c.220A > G polymorphism was significantly associated with ultrasound longissimus muscle depth (ULMD) and IMF, the FASN g.16024A > G polymorphism was significantly associated with ULMD and some body size traits, the SREBP1 84 bp indel was significantly associated with back fat thickness, ULMD and some body size traits. The frequencies of well-characterized A allele in FABP4 c.220A > G in Korean cattle (KOR) and Japanese Black cattle (JB), T allele in SCD g.8586C > T in KOR, SS genotype in SREBP1 84 bp indel in KOR and JB, DELDEL genotype in TCAP g.592-597CTGCAGinsdel in KOR were significantly higher than in Chinese cattle breeds. Thus, the associated four polymorphisms were expected to be genetic selection markers for meat quality, carcass traits and body size of QC.

Keywords: Body size; Carcass traits; Cattle; Intramuscular fat content; Polymorphism.

MeSH terms

Acetophenones
Animals
Body Size
Cattle / genetics
China
Genetic Markers
Genotype
Meat* / analysis
Phenotype
Polymorphism, Single Nucleotide*

Substances

Acetophenones
Genetic Markers
2,2,2',4'-tetrachloroacetophenone