A defective structural zipper in photoreceptors causes inherited blindness

PLoS Biol. 2022 Jun 17;20(6):e3001672. doi: 10.1371/journal.pbio.3001672. eCollection 2022 Jun.

Abstract

Being able to see the beauty of this world is a wonderful thing unfortunately unavailable to people with inherited blindness. In this issue of PLOS Biology, Mercey and colleagues present optimized expansion microscopy for retinal tissue, which represents a huge step forward in our ability to study these blinding conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Blindness* / genetics
  • Humans
  • Retina*

Grants and funding

R.R. is funded by the Landelijke Stichting voor Blinden en Slechtzienden, Stichting Retina Nederland Fonds, Stichting Beheer Het Schild, Stichting Blinden-Penning, and Stichting Steunfonds Uitzicht via Uitzicht 2016/2017-22, together with the Gelderse Blindenstichting, Rotterdamse Stichting Blindenbelangen, Stichting tot Verbetering van het Lot der Blinden ‘Het Lot’, the Stichting voor gehandicapte kinderen Dowilvo, ZonMW (#91216051), and the Foundation Fighting Blindness, USA (PPA-0717-0719-RAD and BR-CMM-0720-0789-RAD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.