Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats

Alfonso Brea Guerrero; Jordan Logue; Kristin Schoepfer; Yi Zhou; Mohamed Kabbaj

doi:10.1016/j.dib.2022.108338

Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats

Data Brief. 2022 Jun 1:43:108338. doi: 10.1016/j.dib.2022.108338. eCollection 2022 Aug.

Authors

Alfonso Brea Guerrero¹, Jordan Logue¹, Kristin Schoepfer¹, Yi Zhou¹, Mohamed Kabbaj¹

Affiliation

¹ Florida State University, College of Medicine, Tallahassee, Florida, USA.

Abstract

In this study, we collected electrophysiological data from acute hippocampal slices of male and female Sprague Dawley rats. Rats were exposed to social isolation rearing and then acutely treated with various doses of ketamine in order to rescue hippocampal plasticity deficits induced by isolation stress. We used two different approaches to study neuronal plasticity: Long-Term Potentiation (LTP) which is a well-established cellular model for memory and Paired-Pulse Facilitation (PPF) which is short-term of presynaptic plasticity. The aim of this article is to offer more experimental details about out LTP and PPF procedures.

Keywords: Estrous cycle; Hippocampus; Ketamine; Long term potentiation; Paired pulse facilitation; Plasticity; Sex differences; Social isolation.