Unbalanced functional connectivity at rest affects the ERP correlates of affective prediction in high intolerance of uncertainty individuals: A high density EEG investigation

Abstract

In a recent study we outlined the link between Intolerance of Uncertainty (IU) and the neural correlates of affective predictions, as constructed by the brain (generation stage) to prepare to relevant stimuli (implementation stage), and update predictive models according to incoming stimuli (updating stage). In this study we further explored whether the brain's functional organization at rest can modulate neural activity elicited within an emotional S1-S2 paradigm as a function of IU and uncertainty of S1-S2 contingencies. We computed resting state functional connectivity (RS-FC) from a 3-min resting period recorded with high density EEG, and we tested whether RS graph theory nodal measures (i.e., strength, clustering coefficient, betweenness centrality) predicted in-task ERP modulation as a function of IU. We found that RS-FC differently predicted in-task ERPs within the generation and updating stages. Higher IU levels were associated to altered RS-FC patterns within both domain-specific (i.e., right superior temporal sulcus) and domain-general regions (i.e., right orbitofrontal cortex), predictive of a reduced modulation of in-task ERPs in the generation and updating stages. This is presumably ascribable to an unbalancing between synchronization and integration within these regions, which may disrupt the exchange of information between top-down and bottom-up pathways. This altered RS-FC pattern may in turn result in the construction of less efficient affective predictions and a reduced ability to deal with contextual uncertainty in individuals high in IU.

Keywords: Affective prediction; ERP; High-density EEG; Intolerance of uncertainty; Resting state functional connectivity; S1-S2 paradigm.