When the brain feels the bugs

Kai Markus Schneider; Christoph A Thaiss

doi:10.1016/j.immuni.2022.05.008

When the brain feels the bugs

Immunity. 2022 Jun 14;55(6):976-978. doi: 10.1016/j.immuni.2022.05.008.

Authors

Kai Markus Schneider¹, Christoph A Thaiss²

Affiliations

¹ Microbiology Department, Institute for Immunology, and Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
² Microbiology Department, Institute for Immunology, and Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: thaiss@pennmedicine.upenn.edu.

PMID: 35705000
DOI: 10.1016/j.immuni.2022.05.008

Abstract

The microbiome modulates brain function, but the precise routes of gut-brain communication remain unclear. In a recent issue of Science, Gabanyi et al. discover that hypothalamic GABAergic neurons directly recognize microbial muropeptides via NOD2, leading to reduced neuronal activity, loss of appetite, and aberrant thermoregulation.

When the brain feels the bugs

Authors

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Abstract

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