Th22 cytokines and yellow fever: Possible implications for the immunopathogenesis of human liver infection

Caio Cesar Henriques Mendes; Jorge Rodrigues de Sousa; Fábio Alves Olímpio; Luiz Fábio Magno Falcão; Marcos Luiz Gaia Carvalho; Jeferson da Costa Lopes; Arnaldo Jorge Martins Filho; Vanessa do Socorro Cabral Miranda; Lais Carneiro Dos Santos; Fellipe Souza da Silva Vilacoert; Vanessa Costa Alves Galúcio; Raimunda do Socorro da Silva Azevedo; Lívia Caricio Martins; Maria Irma Seixas Duarte; Pedro Fernando da Costa Vasconcelos; Juarez Antônio Simões Quaresma

doi:10.1016/j.cyto.2022.155924

Th22 cytokines and yellow fever: Possible implications for the immunopathogenesis of human liver infection

Cytokine. 2022 Sep:157:155924. doi: 10.1016/j.cyto.2022.155924. Epub 2022 Jun 12.

Authors

Caio Cesar Henriques Mendes¹, Jorge Rodrigues de Sousa², Fábio Alves Olímpio³, Luiz Fábio Magno Falcão¹, Marcos Luiz Gaia Carvalho⁴, Jeferson da Costa Lopes⁴, Arnaldo Jorge Martins Filho⁴, Vanessa do Socorro Cabral Miranda⁴, Lais Carneiro Dos Santos⁴, Fellipe Souza da Silva Vilacoert⁴, Vanessa Costa Alves Galúcio⁵, Raimunda do Socorro da Silva Azevedo⁴, Lívia Caricio Martins⁴, Maria Irma Seixas Duarte⁶, Pedro Fernando da Costa Vasconcelos⁷, Juarez Antônio Simões Quaresma⁸

Affiliations

¹ Universidade do Estado do Pará, Belém, PA, Brazil.
² Universidade do Estado do Pará, Belém, PA, Brazil; Instituto Evandro Chagas, Ministério da Saúde, Ananindeua, PA, Brazil.
³ Universidade Federal do Pará, Belém, PA, Brazil.
⁴ Instituto Evandro Chagas, Ministério da Saúde, Ananindeua, PA, Brazil.
⁵ Faculdade Cosmopolita, Belém, PA, Brazil.
⁶ Universidade de São Paulo, São Paulo, SP, Brazil.
⁷ Universidade do Estado do Pará, Belém, PA, Brazil; Instituto Evandro Chagas, Ministério da Saúde, Ananindeua, PA, Brazil. Electronic address: pedro.vasconcelos@uepa.br.
⁸ Instituto Evandro Chagas, Ministério da Saúde, Ananindeua, PA, Brazil; Universidade Federal do Pará, Belém, PA, Brazil; Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address: juarez@ufpa.br.

PMID: 35704977
DOI: 10.1016/j.cyto.2022.155924

Abstract

Yellow fever (YF) is an infectious disease considered a public health problem in tropical and subtropical areas. YF has many pathophysiological events that are correlated with the host immune response. In this study, the in situ Th22 cytokine profile was evaluated. Liver tissue samples were collected from 21 YFV-positive patients who died of the disease and five flavivirus-negative controls who died of other causes and whose hepatic parenchyma architecture was preserved. Immunohistochemical (IHC) analysis of tissues in the hepatic parenchyma of YF cases showed significantly higher expression of interleukin (IL)-22, IL-13, tumour necrosis factor-alpha, and FGF basic (FGF b) in YFV-positive cases than that in flavivirus-negative controls. These results indicate that the response of Th22 cytokines emerges as an alternative for a better understanding of adaptive immunity in the hepatic parenchyma, highlighting the role of cytokines in the repair and suppressive responses in the immunopathogenesis of YFV infection.

Keywords: Immune response; Liver; Th22 cytokines; Yellow fever.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Communicable Diseases*
Cytokines
Flavivirus*
Humans
Liver Diseases*
Yellow Fever* / pathology
Yellow fever virus

Substances

Cytokines