Regulation of RASSF by non-coding RNAs in different cancers: RASSFs as masterminds of their own destiny as tumor suppressors and oncogenes

Ammad Ahmad Farooqi; Gulnara Kapanova; Abay Z Kussainov; Zaure Datkhayeva; Karlygash Raganina; Bolat N Sadykov

doi:10.1016/j.ncrna.2022.04.001

Regulation of RASSF by non-coding RNAs in different cancers: RASSFs as masterminds of their own destiny as tumor suppressors and oncogenes

Noncoding RNA Res. 2022 May 13;7(2):123-131. doi: 10.1016/j.ncrna.2022.04.001. eCollection 2022 Jun.

Authors

Ammad Ahmad Farooqi¹, Gulnara Kapanova^{2

3}, Abay Z Kussainov⁴, Zaure Datkhayeva⁵, Karlygash Raganina⁶, Bolat N Sadykov⁷

Affiliations

¹ Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.
² Al-Farabi Kazakh National University, Almaty, 71 al-Farabi Ave, Almaty, 050040, Kazakhstan.
³ Scientific Center of Anti-infectious Drugs, Kazakhstan, Almaty, 75 a al-Faraby Ave, 050040, Kazakhstan.
⁴ Department of Pediatric Surgery, Kazakh National Medical University, Kazakhstan.
⁵ Department of Obstetrics and Gynecology, Kazakh National Medical University, Kazakhstan.
⁶ Department of Pharmaceutical Technology, Asfendiyarov Kazakh National Medical University, Kazakhstan.
⁷ Department of General Surgery, Kazakhstan Medical University KSPH, Almaty, 050004, Kazakhstan.

Abstract

Ras-association domain family (RASSF) proteins are tumor suppressors and have gained phenomenal limelight because of their mechanistic role in the prevention/inhibition of carcinogenesis and metastasis. Decades of research have demystified wide ranging activities of RASSF molecules in multiple stages of cancers. Although major fraction of RASSF molecules has tumor suppressive roles, yet there is parallel existence of proof-of-concept about moonlighting activities of RASSF proteins as oncogenes. RASSF proteins tactfully rewire signaling cascades for prevention of cancer and metastasis but circumstantial evidence also illuminates oncogenic role of different RASSF proteins in different cancers. In this review we have attempted to provide readers an overview of the complex interplay between non-coding RNAs and RASSF proteins and how these versatile regulators shape the landscape of carcinogenesis and metastasis.

Publication types

Review