Obesity Influences on Patients With Non-valvular Cardiomyopathy in Relation to Early In-Hospital Outcomes and Health System Burden

Ghada Shalaby; Kawlah Samarin; Renan Alabbasi; Amani A Fallatah; Tala Roblah; Rahaf A Abdulwahab; Rawan N Althomali; Emad M Babateen; Faisal Y Alhodian; Sheeren Khaled

doi:10.7759/cureus.24859

Obesity Influences on Patients With Non-valvular Cardiomyopathy in Relation to Early In-Hospital Outcomes and Health System Burden

Cureus. 2022 May 9;14(5):e24859. doi: 10.7759/cureus.24859. eCollection 2022 May.

Authors

Ghada Shalaby^{1

2}, Kawlah Samarin³, Renan Alabbasi³, Amani A Fallatah⁴, Tala Roblah⁵, Rahaf A Abdulwahab³, Rawan N Althomali⁶, Emad M Babateen⁷, Faisal Y Alhodian⁵, Sheeren Khaled^{8

2}

Affiliations

¹ Faculty of Medicine, Zagazig University, Zagazig, EGY.
² Cardiac Center, King Abdullah Medical City, Makkah, SAU.
³ College of Medicine, Umm Al-Qura University, Makkah, SAU.
⁴ College of Medicine, Ibn Sina National College for Medical Studies, Jeddah, SAU.
⁵ College of Medicine, King Abdulaziz University, Jeddah, SAU.
⁶ College of Medicine, King Khalid University, Abha, SAU.
⁷ College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.
⁸ Cardiology, Banha University, Banha, EGY.

Abstract

Background Our study aimed to assess the burden of obesity on the health system and outcomes in patients with non-valvular cardiomyopathy. Methods A retrospective analytical cohort, single-center study was conducted at King Abdullah Medical City (KAMC), Makkah, from June 2019 to June 2020, and includes all non-valvular cardiomyopathy (NVCM) patients. The patients were divided into two groups, obese (BMI≥30) and non-obese (BMI<30). The two groups were compared using a t-test and a chi-squared test for continuous and categorical data and regression analysis. Results A single-center, retrospective study was conducted at KAMC, Makkah, and included all NVCM patients (ejection fraction or EF≤45%) who were admitted during this study period. A total of 626 NVCM patients were included in this cohort study; they had a mean BMI of 29±8.1 and a mean EF of 28.4±9.7. Patients were divided into two groups, obese (BMI≥30) and non-obese (BMI<30). Obese patients represented 37% (n=231) of our study population. The non-ischemic category of cardiomyopathy had a higher prevalence among the obese (35% vs 27%). A higher percentage of obese patients presented with heart failure (HF) symptoms rather than ischemia or arrhythmia (46%, 40%, and 7% for HF symptoms, ischemia, and arrhythmia, respectively). There was no significant difference in NVCM complications, including cardiogenic shock, pulmonary edema, and cardiac arrest, between the two groups. Obese patients had a significantly higher post-myocardial infarction (MI) ejection fraction (29.7±9.7 vs 27.5±9.7, p=0.01). We found a statistically significant positive correlation between BMI and length of in-hospital stay (P=0.04). In-hospital mortality was non-significantly different between our two groups, although numerically, it was higher among the non-obese group (obesity paradox) (10% vs 12%, p=0.2). Type of cardiomyopathy, cerebrovascular stroke, smoking, and sacubitril/valsartan intake were detected as independent predictors of in-hospital mortality among our patients. Conclusions Obesity among NVCM patients sets more burden on health facilities by the prolongation of the in-hospital stay of patients although BMI is not an independent predictor of death in those patients.

Keywords: body mass index: bmi; health system; in-hospital outcome; non-valvular cardiomyopathy; obesity.