A radiation resistance related index for biochemical recurrence and tumor immune environment in prostate cancer patients

Zhi-Bin Ke; Qi You; Jia-Yin Chen; Jiang-Bo Sun; Yu-Ting Xue; Rui-Bin Zhuang; Qing-Shui Zheng; Ye-Hui Chen; Yong Wei; Xiong-Lin Sun; Xue-Yi Xue; Ning Xu

doi:10.1016/j.compbiomed.2022.105711

A radiation resistance related index for biochemical recurrence and tumor immune environment in prostate cancer patients

Comput Biol Med. 2022 Jul:146:105711. doi: 10.1016/j.compbiomed.2022.105711. Epub 2022 Jun 7.

Authors

Affiliations

¹ Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
² Department of Urology, Quangang District Hospital, Quanzhou, 362100, China.
³ Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Fujian Key Laboratory of Precision Medicine for Cancer, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. Electronic address: xuexueyi@fjmu.edu.cn.
⁴ Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Fujian Key Laboratory of Precision Medicine for Cancer, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. Electronic address: drxun@fjmu.edu.cn.

PMID: 35701253
DOI: 10.1016/j.compbiomed.2022.105711

Abstract

Purpose: To establish and verify a novel radiation resistance related index for predicting biochemical recurrence and tumor immune environment in prostate cancer (PCa) patients.

Materials and methods: The transcriptome information of PCa were obtained from GEO and TCGA portal. We identified radiation resistance related genes (RRGs) between radioresistant and radiosensitive PCa cells. We conducted multivariate Cox analysis to construct a novel radiation resistance related index for predicting biochemical recurrence (BCR)-free survival (BCRFS). Internal and external validations were conducted. Preliminary experimental verifications were performed.

Results: We identified 194 differentially expressed RRGs and three radiation resistance related molecular clusters for PCa. Moreover, we established a novel radiation resistance related index and succeeded in conducting internal and external validations. High-risk populations meant significantly worse BCRFS in training, testing and validating cohort. The area under receiver operating characteristic curve were 0.809, 0.698, and 0.712 in training, testing, and validating cohort. The immune microenvironment was significantly different between high and low-risk score patients. Preliminary experiment identified and validated three potential biomarkers related to radiation resistance (ZNF695, TM4SF19, CCDC3) of PCa.

Conclusions: This study successfully established and verified a novel radiation resistance related index, which had an excellent performance in predicting BCR and tumor immune microenvironment in patients with PCa.

Keywords: Biochemical recurrence; Prostate cancer; Radiation resistance; Tumor immune microenvironment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Male
Prostatic Neoplasms* / genetics
Prostatic Neoplasms* / radiotherapy
ROC Curve
Risk Factors
Tumor Microenvironment / genetics