Recent Advances in Synthesis of Multiply Arylated/Alkylated Pyridines

Abstract

Multiply aryl/alkyl-substituted pyridines are some of the untapped synthetic targets because of the challenge in regioselectively introducing less polar aryl/alkyl groups at the desired positions in the pyridine framework. Interestingly, the importance of this family of compounds has increased annually, particularly in biological and materials engineering applications. The syntheses of such pyridines have been extensively reported, but there is a lack of comprehensive review articles. Hence, this review discusses recent advances by grouping reaction patterns that generally deliver tri-, tetra-, and penta-aryl/alkyl pyridines.

Keywords: Cross-coupling; Cycloaddition; Multi-component reactions; Nitrogen heterocycles; Synthetic methods.