Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity

Debabrata Maity; Yujeong Oh; Lothar Gremer; Wolfgang Hoyer; Mazin Magzoub; Andrew D Hamilton

doi:10.1002/chem.202201698

Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity

Chemistry. 2022 Jul 6;28(38):e202201698. doi: 10.1002/chem.202201698. Epub 2022 Jun 14.

Authors

Debabrata Maity^{1

2}, Yujeong Oh³, Lothar Gremer^{4

5}, Wolfgang Hoyer^{4

5}, Mazin Magzoub³, Andrew D Hamilton¹

Affiliations

¹ Department of Chemistry, New York University, New York, NY, 10003, USA.
² Present Address: Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, 500007, India.
³ Biology Program, New York University Abu Dhabi, P.O. Box 129188, Saadiyat Island Campus, Abu Dhabi, United Arab Emirates.
⁴ Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40225, Düsseldorf, Germany.
⁵ Institute of Biological Information Processing (IBI-7: Structural Biochemistry) and JuStruct: Jülich Center for Structural Biology, Forschungszentrum Jülich, 52425, Jülich, Germany.

PMID: 35701098
DOI: 10.1002/chem.202201698

Abstract

Invited for the cover of this issue is the group of Prof. Hamilton at New York University. The image depicts how cucurbit[7]uril inhibits islet amyloid polypeptide self-assembly that rescues rat insulinoma cells (a pancreatic β-cell model) from assembly-associated cytotoxicity. Read the full text of the article at 10.1002/chem.202200456.

MeSH terms

Amyloid
Animals
Bridged-Ring Compounds / pharmacology
Heterocyclic Compounds, 2-Ring
Humans
Imidazoles / pharmacology
Imidazolidines
Insulin-Secreting Cells*
Islet Amyloid Polypeptide*
Macrocyclic Compounds
Rats

Substances

Amyloid
Bridged-Ring Compounds
Heterocyclic Compounds, 2-Ring
Imidazoles
Imidazolidines
Islet Amyloid Polypeptide
Macrocyclic Compounds
cucurbit(7)uril