Research progress on classical traditional Chinese medicine Taohong Siwu decoction in the treatment of coronary heart disease

XueZhen Wang; Tong Wang; YingZheng Wang; Xiao Li; Qian Chen; Yuan Wang; Xiaoyu Zhang; HuaXin Wang; HaiJun Zhao; Yue Mou; Lei Xia; YaNan Zhang

doi:10.1016/j.biopha.2022.113249

Research progress on classical traditional Chinese medicine Taohong Siwu decoction in the treatment of coronary heart disease

Biomed Pharmacother. 2022 Aug:152:113249. doi: 10.1016/j.biopha.2022.113249. Epub 2022 Jun 13.

Authors

XueZhen Wang¹, Tong Wang², YingZheng Wang¹, Xiao Li¹, Qian Chen¹, Yuan Wang¹, Xiaoyu Zhang¹, HuaXin Wang¹, HaiJun Zhao¹, Yue Mou¹, Lei Xia¹, YaNan Zhang³

Affiliations

¹ College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shangdong Province 250355, China; Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, Jinan, Shangdong Province 250355, China.
² School of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shangdong Province 250355, China.
³ College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shangdong Province 250355, China; Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, Jinan, Shangdong Province 250355, China. Electronic address: zyn8326@163.com.

PMID: 35700678
DOI: 10.1016/j.biopha.2022.113249

Abstract

The pathogenesis of coronary heart disease is closely related to blood stasis. Taohong Siwu decoction (THSW for short) is one of the most widely used prescriptions for activating blood and removing stasis. Clinical research has confirmed its curative effect on coronary heart disease. However, its underlying mechanism remains unclear. Therefore, this paper reviewed the clinical efficacy of THSW and determine its effective components based on a comprehensive literature review. Furthermore, the core components and targets of THSW in treating coronary heart disease using molecular docking were verified, and the interaction sites were predicted to construct a theoretical basis for the clinical application of THSW.

Keywords: Clinical role; Coronary heart disease; Pharmacological mechanism; Taohong Siwu decoction.

Publication types

Review

MeSH terms

Coronary Disease* / drug therapy
Drugs, Chinese Herbal* / therapeutic use
Humans
Medicine, Chinese Traditional
Molecular Docking Simulation

Substances

Drugs, Chinese Herbal
Taohong Siwu decoction II