"Kissing" basaloid follicular hamartomas of the eyelid

J Cutan Pathol. 2022 Oct;49(10):881-884. doi: 10.1111/cup.14273. Epub 2022 Jul 5.

Abstract

Basaloid follicular hamartomas (BFHs) are rare, benign, cutaneous adnexal tumors characterized by branching cords and anastomosing strands of basaloid cells in a loose, fibrous stroma. BFHs exhibit variable clinical presentations although they are commonly observed as skin-colored papules and are diagnosed based on histopathological features. Common systemic diseases associated with BFH include alopecia, myasthenia gravis, and palmoplantar pitting. BFH of the eyelid is extremely rare with only five cases reported in the literature to date. Congenital "kissing" lesions have only previously been reported with nevi. Here, we present a novel case of congenital "kissing" BFH of the right upper and right lower eyelid, and histopathological examination revealed intradermal nodules of basaloid cells forming reticulated strands, pseudohorn cysts, mucinous stroma, and palisading with CD34 and Bcl-2 expression in the stromal fibroblasts and periphery, respectively.

Keywords: basaloid follicular hamartoma; congenital “kissing” lesion; “kissing” nevus.

Publication types

  • Case Reports

MeSH terms

  • Eyelids / pathology
  • Hamartoma* / pathology
  • Humans
  • Proto-Oncogene Proteins c-bcl-2
  • Skin Diseases* / pathology
  • Skin Neoplasms* / pathology

Substances

  • Proto-Oncogene Proteins c-bcl-2