Copper boron-imidazolate framework incorporated chitosan membranes for bacterial-infected wound healing dressing

Abstract

Chronic wounds resulting from bacterial infection are a global healthcare challenge as they usually impair the healing process and induce various complications. In this work, a chitosan (CS) membrane loaded with copper boron-imidazolate framework (Cu-BIF) was successfully prepared by self-assembly method for bacterial-infected wound-healing dressing. The as-prepared Cu-BIF/CS membrane possessed desirable biocompatibility. The antibacterial activity of Cu-BIF/CS membrane was evaluated by the spread plate and disc diffusion method, which was also verified by the fluorescence-based viability and morphological changes of bacteria. Moreover, Cu-BIF/CS membrane could increase wound closure rate and accelerate skin regeneration via combination therapy with chitosan, Cu²⁺ and hydroxyl radicals during infected wound healing process. These results exhibit that Cu-BIF/CS membrane has great potential as wound dressings in the field of clinical treatment of bacterial-infected wounds.

Keywords: Antibacterial; Boron–imidazolate frameworks; Chitosan; Membrane; Wound dressing.